About:
Chief Medical Officer
BBiomed Sci Hon (Mon), MA(Cantab), BM BCh(Oxon), MRCS (Eng), FC Neurosurg (SA), MMed Neurosurg (Wits), CMIN C Teo Fellowship (Sydney)
Dr Christos Profyris completed his pre-clinical medical studies at the University of Cambridge with a Double First Class and went on to finish his medical degree with Distinction at the University of Oxford.
He completed his Neurosurgical training at the University of Witwatersrand and achieved his Neurosurgery Fellowship qualification from the The Colleges of Medicine of South Africa. He also holds a Master of Medicine in Neurosurgery from the University of the Witwatersrand.
During the completion of the esteemed Aesculap Charles Teo Minimally Invasive Neurosurgery Fellowship at The Centre for Minimally Invasive Neurosurgery in Sydney, Australia, Dr. Profyris had the opportunity to pursue advanced training in brain mapping techniques and TMS applications.
This additional expertise was acquired under the guidance of Professor Mike Sughrue, a globally renowned expert in brain mapping. Notably, Professor Sughrue has an extensive publication record of over 250 peer-reviewed publications and is the founder of Omniscient Neurotechnology.
Being a super-specialist in brain tumour and vascular neurosurgery Dr Profyris has published over 20 peer-reviewed publications.
He has an active research interest in the application of connectome based TMS treatment.
Should you wish to contact Dr Christos Profyris regarding a research or a recent publication please feel free to contact us.
Videos
The Connectome Revolution - Episode #1
The Connectome Revolution - Episode #2
The Connectome Revolution - Episode #3
The Connectome Revolution - Episode #4
The Connectome Revolution - Episode #5
The Connectome Revolution - Episode #6
WiSH Webinar: Brain Mapping and Connectomes in the Context of Concussion
WiSH Webinar: Brain Mapping and Connectomes in the Context of Concussion
The Human Connectome Project - Relating Brain Circuits to Behavior: David Van Essen at TEDxCaltech
Webinar with Dr Christos Profyris: Brain Tumour Surgery - The Future
Articles / News:
Interventional neurorehabilitation for promoting functional recovery post-craniotomy: a proof-of-concept.
https://pubmed.ncbi.nlm.nih.gov/35197490/
Poologaindran A, Profyris C, Young IM, Dadario NB, Ahsan SA, Chendeb K, Briggs RG, Teo C, Romero-Garcia R, Suckling J, Sughrue ME.
Sci Rep. 2022 Feb 23;12(1):3039. doi: 10.1038/s41598-022-06766-8.
PMID: 35197490 Free PMC article.
Resection of Symptomatic Pineal Cysts Provides Durable Clinical Improvement: A Breakdown of Presenting Symptoms and Lessons Learned.
https://pubmed.ncbi.nlm.nih.gov/33771749/
Yeung JT, Young IM, Profyris C, Katsos K, Sughrue ME, Teo C.
World Neurosurg. 2021 Jun;150:e668-e674. doi: 10.1016/j.wneu.2021.03.087. Epub 2021 Mar 23.
PMID: 33771749
Ruptured presentation of superficial temporal artery pseudoaneurysm treated with anastomotic repair: Case report.
https://pubmed.ncbi.nlm.nih.gov/35128023/
Ndlovu B, Mkhaliphi MM, Leola K, Mpanza MN, Ouma JR, Profyris C.
Trauma Case Rep. 2022 Jan 26;38:100615. doi: 10.1016/j.tcr.2022.100615. eCollection 2022 Apr.
PMID: 35128023 Free PMC article.
Anaplastic Oligodendroglioma – Is Adjuvant Radiotherapy Mandatory following Maximal Surgical Resection?: Grade 3 Oligo Radiotherapy.
https://pubmed.ncbi.nlm.nih.gov/33109468/
Profyris C, Chen E, Young IM, Chendeb K, Ahsan SA, Briggs RG, Sughrue ME, Teo C.
Clin Neurol Neurosurg. 2021 Jan;200:106303. doi: 10.1016/j.clineuro.2020.106303. Epub 2020 Oct 15.
PMID: 33109468
Pharmacotherapeutic options for atypical meningiomas.
https://pubmed.ncbi.nlm.nih.gov/31322413/
Ahsan SA, Chendeb K, Profyris C, Teo C, Sughrue ME. Expert Opin Pharmacother. 2019 Oct;20(15):1831-1836. doi: 10.1080/14656566.2019.1643840. Epub 2019 Jul 19.
Papillary tumour of the pineal region: a case report
https://ejnpn.springeropen.com/articles/10.1186/s41983-020-00188-x
Bromfield M, Profyris C, Mehtar A, Du Toit M, Wadee R. The Egyptian J of Neurol, Psych and Neurosurg. 2020 56, 55(20)
Brain tumours: An update
Profyris C
Neuron SA Volume 12 No1 Issue 38 2019
Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics Part II. Strategies to reduce scar formation after dermatologic procedures.
https://pubmed.ncbi.nlm.nih.gov/22177632/
Tziotzios C, Profyris C, Sterling J. J Am Acad Dermatol. 2012 Jan;66(1):13-24; quiz 25-6. doi: 10.1016/j.jaad.2011.08.035. Review.
Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics Part I. The molecular basis of scar formation.
https://pubmed.ncbi.nlm.nih.gov/22177631/
Profyris C, Tziotzios C, Do Vale I. J Am Acad Dermatol. 2012 Jan;66(1):1-10; quiz 11-2. doi: 10.1016/j.jaad.2011.05.055. Review.
Delayed management of penetrating cardiac injury – less urgency, more options
Profyris C, Rosic T, Moeng, MS, Ziprin P
Injury Extra 42(8):83-84 August 2011
Solitary fibrous tumour of the face: a rare case report.
https://pubmed.ncbi.nlm.nih.gov/19527945/
Profyris C, Soilleux E, Corkill R, Birch J. J Plast Reconstr Aesthet Surg. 2010 Jan;63(1):e13-5. doi: 10.1016/j.bjps.2009.05.026. Epub 2009 Jun 13.
Leukemia inhibitory factor arrests oligodendrocyte death and demyelination in spinal cord injury.
https://pubmed.ncbi.nlm.nih.gov/16957585/
Azari MF, Profyris C, Karnezis T, Bernard CC, Small DH, Cheema SS, Ozturk E, Hatzinisiriou I, Petratos S. J Neuropathol Exp Neurol. 2006 Sep;65(9):914-29.
Incomplete Freund’s adjuvant enhances locomotor performance following spinal cord injury.
https://pubmed.ncbi.nlm.nih.gov/16324097/
Azari MF, Karnezis T, Bernard CC, Profyris C, LeGrande MR, Zang DW, Cheema SS, Petratos S. Eur J Neurol. 2005 Dec;12(12):1004-8.
Induction of endogenous neural precursors in mouse models of spinal cord injury and disease.
https://pubmed.ncbi.nlm.nih.gov/16053474/
Azari MF, Profyris C, Zang DW, Petratos S, Cheema SS.. Eur J Neurol. 2005 Aug;12(8):638-48.
Effects of intraperitoneal injection of Rofecoxib in a mouse model of ALS.
https://pubmed.ncbi.nlm.nih.gov/15804265/
Azari MF, Profyris C, Le Grande MR, Lopes EC, Hirst J, Petratos S, Cheema SS. Eur J Neurol. 2005 May;12(5):357-64.
Molecular mechanisms in Schwann cell survival and death during peripheral nerve development, injury and disease.
https://pubmed.ncbi.nlm.nih.gov/15639806/
Boyle K, Azari MF, Profyris C, Petratos S. Neurotox Res. 2005;7(1-2):151-67. Review.
Expression of the low-affinity neurotrophin receptor, p75(NTR), is upregulated by oligodendroglial progenitors adjacent to the subventricular zone in response to demyelination.
https://pubmed.ncbi.nlm.nih.gov/15326616/
Petratos S, Gonzales MF, Azari MF, Marriott M, Minichiello RA, Shipham KA, Profyris C, Nicolaou A, Boyle K, Cheema SS, Kilpatrick TJ. Glia. 2004 Oct;48(1):64-75.
Degenerative and regenerative mechanisms governing spinal cord injury.
https://pubmed.ncbi.nlm.nih.gov/15056450/
Profyris C, Cheema SS, Zang D, Azari MF, Boyle K, Petratos S. Neurobiol Dis. 2004 Apr;15(3):415-36. Review.
Seminars / Workshops
2022
- Nov – Advanced Neurosurgical Anatomy Hands-on Cadaver Course_Part 2 Posterior Arterial Circulation and Cerebral Venous Anatomy_Wits Surgical Skills Lab – Course Director: C Profyris
- Oct – South African Neurosurgical Society (SNSA) Congress_Transorbital Approach: Surgical Case Series_Platform Presentation: C Profyris
- Oct – South African Neurosurgical Society (SNSA) Congress_Review of Endoscopic Use: 100 Endoscopic Cranial Surgical Cases_Platform Presentation: C Profyris
- Oct – South African Neurosurgical Society (SNSA) Congress_Transcranial Magnetic Stimulation: Pre-Operative and Post-Operative Use-Case in Neuro-Oncology_Flash Presentation: C Profyris
- Oct – South African Neurosurgical Society (SNSA) Congress_Review of Endoscopic Use: Surgical Management of Colloid Cysts: Case Series_ Flash Presentation: C Profyris
- June: RMB Healthcare Innovation Forum – The Systemic Mental Health Challenge_Applying Personalised Brain Mapping to Treatment of Mental Health Conditions with TMS_Presenter: C Profyris
- May – Advanced Neurosurgical Anatomy Hands-on Cadaver Course_Part 1 Anterior Cerebral Circulation_Wits Surgical Skills Lab – Course Director: C Profyris
- Apr – South African Neurosurgical Society (SNSA) Grand Round Series 2022_Orbital Tumours: Anatomy, Pathology and Personal Case Series_Presenter: C Profyris
- Apr – Clinix Health Group Webinar_Brain Tumour Surgery – The Future_Presenter: C Profyris
- Mar – Wits Sport and Health (WiSH) Congress_Brain Mapping and Concussion_Platform Presentation: C Profyris
2021
- Nov – Clinical TMS Society November Grand Round Webinar (International Society)_The Connectome Revolution and TMS Applications_Presenter: C Profyris
- Oct – South African Neurosurgical Society (SNSA) Congress_Extended endoscopic endonasal techniques in the treatment of giant pituitary adenomas: personal series_ Platform Presentation: C Profyris
- Oct – South African Neurosurgical Society (SNSA) Congress_Surgical Case Series of Keyhole Approaches Applied to Clipping of Acutely Ruptured Intracerebral Aneurysms_ Platform Presentation: C Profyris
- Oct – South African Neurosurgical Society (SNSA) Congress_Keyhole Supraorbital Approach – techniques and applications_ FlashPresentation: C Profyris
- Oct – South African Neurosurgical Society (SNSA) Congress_Tractorgraphic Planning Applied to Glioma Surgery_ Platform Presentation: C Profyris
- Oct – South African Neurosurgical Society (SNSA) Congress_The Connectome – Neurosurgical Applications_ Platform Presentation: C Profyris
- Oct – South African Neurosurgical Society (SNSA) Congress_Endoscopic Treatment of Hemifacial Spasm via Microvascular Decompression (MVD) – Personal Series_ Flash Presentation: C Profyris
- Jul – Wits Sport and Health (WiSH) Webinar_Brain Mapping and Connectomics in the context of Concussion_Presenter: C Profyris
- Jun – International Neurosurgery Symposium – Vascular Neurosurgery Updates Webinar (India)_ Keyhole Approaches to Cerebral Aneurysm Surgery_Presenter: C Profyris
- Apr _Connectome and TMS Lecture Series – The Connectome Revolution: Episode 6 – The Connectome in Disease and TMS Applications_Presenter: C Profyris
- Apr _Connectome and TMS Lecture Series – The Connectome Revolution: Episode 5 – Parietal and Occipital Lobe Parcellation Map_Presenter: C Profyris
- Apr _Connectome and TMS Lecture Series – The Connectome Revolution: Episode 4 – Temporal Lobe, Insula and Opercula Parcellation Map_Presenter: C Profyris
- Apr _Connectome and TMS Lecture Series – The Connectome Revolution: Episode 3 – Frontal Lobe Parcellation Map_Presenter: C Profyris
- Apr _Connectome and TMS Lecture Series – The Connectome Revolution: Episode 2 – Brain Architectonics, Development, Graph Theory and Tracts_Presenter: C Profyris
- Apr _Connectome and TMS Lecture Series – The Connectome Revolution: Episode 1 – Introduction_Presenter: C Profyris
2019
- State-of-the-Art Endoscopic Skull Base Surgery: A Hands-On Course : Ohio, United States
- Pacific Rim Master Class in Endoscopic Endonasal and Keyhole Surgery : California, United States
2018
- Seventh annual world course in brain tumour surgery : London, United Kingdom
- Multiportal approaches to the skull base – 2nd International Hands-on Course : Vienna, Austria