Skip links

Connectomix - Leading TMS application in health and science

Our publications

Want more information about Connectomix or our TMS research for your organisation?

Welcome to the Connectomix publications page. Explore our collection of groundbreaking research articles, scientific papers, and publications in neuroscience and brain mapping. 

Our publications reflect our commitment to rigorous research, innovative methodologies, and cutting-edge technologies. Delve into diverse topics such as brain connectivity, neural networks, neuroimaging techniques, and computational neuroscience. 

Each publication represents our dedication to contributing to the scientific community and driving progress in the field. Whether you’re a researcher or curious about the latest advancements in neuroscience, our publications offer valuable insights and perspectives. 

Stay informed and explore the frontiers of brain research with Connectomix. Together, let’s unravel the mysteries of the brain and enhance our understanding of the human mind.

Recent research articles

Interventional neurorehabilitation for promoting functional recovery post-craniotomy: a proof-of-concept
2022 Feb 23;12(1):3039. doi: 10.1038/s41598-022-06766-8.
PMID: 35197490 
PMCID: PMC8866464
DOI: 10.1038/s41598-022-06766-8


The human brain is a highly plastic ‘complex’ network-it is highly resilient to damage and capable of self-reorganisation after a large perturbation. Clinically, neurological deficits secondary to iatrogenic injury have very few active treatments. New imaging and stimulation technologies, though, offer promising therapeutic avenues to accelerate post-operative recovery trajectories.

In this study, we sought to establish the safety profile for ‘interventional neurorehabilitation’: connectome-based therapeutic brain stimulation to drive cortical reorganisation and promote functional recovery post-craniotomy. In n = 34 glioma patients who experienced post-operative motor or language deficits, we used connectomics to construct single-subject cortical networks.

Based on their clinical and connectivity deficit, patients underwent network-specific transcranial magnetic stimulation (TMS) sessions daily over five consecutive days. Patients were then assessed for TMS-related side effects and improvements. 31/34 (91%) patients were successfully recruited and enrolled for TMS treatment within two weeks of glioma surgery. No seizures or serious complications occurred during TMS rehabilitation and 1-week post-stimulation. Transient headaches were reported in 4/31 patients but improved after a single session.

No neurological worsening was observed while a clinically and statistically significant benefit was noted in 28/31 patients post-TMS. We present two clinical vignettes and a video demonstration of interventional neurorehabilitation. For the first time, we demonstrate the safety profile and ability to recruit, enroll, and complete TMS acutely post-craniotomy in a high seizure risk population.

Given the lack of randomisation and controls in this study, prospective randomised sham-controlled stimulation trials are now warranted to establish the efficacy of interventional neurorehabilitation following craniotomy.

Recent videos

This website uses cookies to improve your web experience.