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Leading TMS therapy in South Africa

Connectomix is a state-of-the-art TMS clinic group founded in 2019 and based in Johannesburg, Pretoria and Cape Town. It is backed by Netcare, the largest private hospital group in South Africa.

By personalising TMS treatments through sophisticated MRI imaging algorithms, Connectomix has become a hub of excellence for Depression, Anxiety and Neuro-rehabilitation treatments.


Are you or someone you care about struggling with depression?

We offer individualised TMS therapy treatment for depression.

Are you suffering from depression?

If you are seeking effective depression treatment, our transformative approach can be the key to reclaiming your life.

Our specialized TMS therapy targets the neural circuits associated with depression, promoting positive changes in brain activity.

By tailoring the treatment to your unique needs, we address the root causes of your depression, aiming for lasting improvement and enhanced well-being. 

Take the first step towards a brighter future and book a consultation today to explore how Connectomix’s personalized TMS therapy can help reduce depression symptoms and restore hope in your life.


We believe in providing a seamless travel experience.

As your dedicated partner, Connectomix takes care of every detail, including bookings, flights, accommodation, and transfers, so you can focus on relaxation and rejuvenation.

With Connectomix, you can rest assured that every aspect of your journey will be handled with utmost care and attention, enabling you to embark on your TMS therapy treatment with peace of mind.


Our team will assist with travel arrangements.


We take care of all flight bookings.


Travel experiences to suite your requirements.


We coordinate transfers between treatment and travel


Our team will assist with travel arrangements.


We take care of all flight bookings.


Travel experiences to suite your requirements.


We coordinate transfers between treatment and travel

Experience the seamless process of personalised TMS therapy, luxury accommodation, and optimal safari, all guided by Connectomix expert team.

tms safari cheap

Virtual consultation

The first step is a virtual consultation. During this consultation, we carefully assess your needs and discuss your specific requirements in detail. We will provide you with all the necessary information required in order to aid you in your decision making.

Arrival in South Africa

Our team will welcome you as soon as you arrive and offer you a VIP experience. Our dedicated team takes care of all the necessary arrangements, including comfortable transfers and seamless logistics, allowing you to relax and soak in the vibrant and sunny atmosphere.


This is the start of your treatment. You will be transferred to one of our clinics where you will meet our team and as part of our comprehensive approach to personalized medicine, we will conduct an MRI (Magnetic Resonance Imaging) scan.

The information gathered from this scan will allow us to use artificial intelligence to construct your personalised brain map.

This comprehensive assessment allows our expert team to identify specific regions of interest and determine the optimal targets for TMS stimulation. This will tailor treatment to your specific needs and unlock your brain's full potential for recovery and well-being. Welcome to the heart of your transformative journey at Connectomix—TMS (Transcranial Magnetic Stimulation) treatments.


Our expert team will welcome you and guide you through your week long TMS treatment process.

During your TMS treatments, you will be comfortably seated in a relaxed environment and our state-of-the-art TMS technology will precisely deliver targeted magnetic pulses to specific areas of your brain, as guided by your personalised brain map.
Our experienced clinicians will carefully monitor your progress and adjust the treatment parameters to ensure the best outcomes. Following each treatment session, you will be able to relax within our restful clinic environment.
Embark on this transformative journey with Connectomix and experience the positive impact of TMS therapy in revitalizing your mind, restoring your well-being, and paving the way for a brighter future.

Optional > Safari

Enhance your transformative journey with Connectomix by embarking on an optional safari adventure.
After your TMS treatments, immerse yourself in the captivating landscapes of South Africa.
Relax in luxurious accommodations that blend seamlessly with the surroundings.
Our carefully curated bespoke packages offer the perfect balance of relaxation, connection with nature, and unforgettable experiences crafted to meet your expectations.
Create lasting memories in the heart of the African wilderness. Experience our big 5 (lion, leopard, elephant, rhinoceros and buffalo) from up-close and allow our bespoke safaris experience to complement the positive effects of your TMS treatments.

Return home

We will ensure a smooth and seamless transition for your return home and take care of all the necessary travel arrangements to make your journey back as comfortable as possible

tms safari cheap

Our Clinics

We take pride in its state-of-the-art clinics, where innovation and comfort converge.

Our clinics are equipped with cutting-edge technology and modern facilities, ensuring the highest standard of care for our patients. From the moment you step through our doors, you will experience a welcoming and soothing environment designed to promote relaxation and well-being.

Centrally located within Johannesburg and Pretoria our clinics have been designed to give you a seamless treatment experience from start to finish. Every detail has been carefully crafted to enhance your comfort and address your needs.


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Connectomix Milpark, located within the esteemed Netcare Milpark Hospital. Centrally located in Johannesburg.


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Connectomix Menlyn Maine is located in Menlyn, Pretoria. Easily accessible from surrounding suburbs and major roadways.

Cape Town,
Coming soon

Connectomix Cape Town, coming soon.

All our TMS plans and treatments are conducted with extreme care and are personalised to give you the best possible chance for a successful treatment response.

Our Treatments

What is TMS diagram

What is TMS?

TMS (Transcranial Magnetic Stimulation) is a non-invasive out-patient based procedure used for the treatment of different mood disorders such as depression and anxiety. It is also successfully used for neuro-rehabilitation.

What is TMS diagram

TMS relies on the generation of brief magnetic fields created by an insulated coil that is placed over the scalp. These magnetic fields, in turn, create weak electric currents in the brain that achieve brain stimulation by activating neural circuitry at the site of stimulation.

By stimulating brain circuits, TMS aims to reset neural circuits and induce a change in their activity in order to bring about an improvement in conditions such as depression and anxiety.

What is standard TMS?

Traditional TMS, practiced in most TMS centres around the world, relies on blanket stimulation over the left side of the head.

The exact site of stimulation is generally derived by placing a cap over the head and obtaining the target area by measuring distances from landmarks such as the nose or with a target point drawn onto the cap.

With this approach, for obvious reasons, the actual brain stimulation site varies tremendously between people. Variation is not only due to differences in the shape of our skull but more importantly variation is the result of significant difference between people’s brains. In one recent reputable study, it was shown that this traditional approach can lead to over 50% of brain stimulation sites being off-target, during treatment.

Variation is not only due to differences in the shape of our skull but more importantly variation is the result of significant difference between people’s brains.

tms treatment session

TMS Coil

TMS coils delivers magnetic pulses to targeted regions

Our core value at the Connectomix advanced clinics, is to individualise your TMS treatment by applying principles of personalised brain medicine.

The human brain, composed of 86 billion brain cells that fire on average 17 trillion times per second is the most complex structure in existence. This miracle of creation is responsible for who we are – our ability to talk, to walk, our thoughts, our actions, our feelings…

Clearly, every brain and by extension, every person is unique. Until recently, understanding individual brain connection variations between people was not possible.

Through breakthroughs in both MRI imaging and AI, we are now able to understand these variations and build personalised brain maps that allow us to individualise TMS targets, based on your own brain (big)data. This personalised brain data approach to TMS has recently been accepted as a superior treatment method by the US Food and Drug Administration (FDA)2.

At Connectomix, we arrange an MRI scan (Approximately 25 minutes) that allows us to obtain highly sophisticated information about your brain connections.

We process this information with machine learning algorithms that allow us to understand how different parts of your brain are talking to each other in the form of brain networks. By analysing your brain networks, in conjunction with your clinical symptoms, we are able to pin-point the areas of your brain, that have the highest probability of treatment response to TMS. Hence, we are applying personalised brain medicine to your clinical problem.

As we are using highly sophisticated brain maps to pin-point TMS targets, targeting accuracy is central to the service we provide and blanket stimulation of the left side of the head, as employed in traditional TMS, is not an option.

At Connectomix we use sophisticated brain navigation technology that allows us to pinpoint brain areas on your scalp with millimetre accuracy. We also have extensive procedures in place to ensure accurate TMS targeting is achieved.

In Summary, Connectomix aims to provide world-class TMS treatment that is based on deep scientific understanding of human brain connections and cutting-edge technology.

1. Neuronavigation maximizes accuracy and precision in TMS positioning: Evidence from 11,230 distance, angle, and electric field modeling measurements. Caulfield KA, Fleischmann HH, Cox CE, Wolf JP, George MS, McTeague LM.Brain Stimul. 2022 Sep-Oct;15(5):1192-1205. doi: 10.1016/j.brs.2022.08.013. Epub 2022 Aug 27.PMID: 36031059

Why is TMS at Connectomix different? How is it personalised?

Brain map

Brain map

Brain map

Brain map

Brain map

Brain map

Our strategic partnership with Netcare Group, who operate 53 hospitals and 12 mental health facilities throughout southern Africa, enhances Connectomix service and product offerings by introducing new advanced healthcare related technology throughout South Africa.

Trusted by Netcare

Dedicated team

VIP Treatment

State-of-the-art Clinics

TMS and Safari

Depression and Anxiety

Improve your mental health with Connectomix. We are constantly assessing our treatment responses to ensure that all our TMS protocols are optimised.

Connectomix TMS for Depression

81% of patients with depression that were treated at Connectomix, had a significant improvement with our advanced TMS treatment protocol.

Patients experienced improvement


Level of depression

Ups and Downs (Normal)


Mild Mood Disturbance


Borderline Clinical Depression


Moderate Depression


Severe Depression


Extreme Depression

Change in level of depression

Improvement of 3 levels


Same level of depression


Improvement of 1 level


Improvement of 2 levels


Improvement of 4 levels


Improvement of 5 levels


Connectomix TMS for Anxiety

64% off patients with anxiety that were treated at Connectomix, had a significant improvement with our advanced TMS treatment protocol

Patients experienced improvement


Level of anxiety

Minimal anxiety


Mild anxiety


Moderate anxiety


Severe anxiety

Change in level of anxiety

Same level of anxiety


Improvement of 2 levels


Improvement of 1 level


Improvement of 3 levels



Step 1

Contact us

Start your journey today.

Step 2


Get advise from our experts.


Step 3

Treatment plan

Liaise with your treatment coordinator with any questions/ thoughts that you may have.


Step 4


Augment your mental health with personalised TMS treatment.


Step 5 (optional)


Should you wish, why not enjoy the African sun with an exclusive safari experience


dr chris
dr chris

Chief Medical Officer

BBiomed Sci Hon (Mon), MA(Cantab), BM BCh(Oxon), MRCS (Eng), FC Neurosurg (SA), MMed Neurosurg (Wits), CMIN C Teo Fellowship (Sydney)

Dr Christos Profyris completed his pre-clinical medical studies at the University of Cambridge with a Double First Class and went on to finish his medical degree with Distinction at the University of Oxford.

He completed his Neurosurgical training at the University of Witwatersrand and achieved his Neurosurgery Fellowship qualification from the The Colleges of Medicine of South Africa. He also holds a Master of Medicine in Neurosurgery from the University of the Witwatersrand.

During the completion of the esteemed Aesculap Charles Teo Minimally Invasive Neurosurgery Fellowship at The Centre for Minimally Invasive Neurosurgery in Sydney, Australia, Dr. Profyris had the opportunity to pursue advanced ...


Have more questions about TMS? Our FAQ page will provide answers to your questions.

What is TMS?

Want to know more about what TMS is and how Connectomix personalises our treatments?

Who we are

Learn more about Connectomix, what we do. We provide additional information about our team.

Connectomix is making headlines in the news, garnering attention for its groundbreaking advancements in mental health care. Stay informed and discover how Connectomix is revolutionizing treatments, transforming lives, and shaping the future of mental wellness.

Download an information pack

Do you want more information about how Connectomix can help you through our TMS and brain mapping treatment? Download the Connectomix information pack and get all the information you'll need to make an informed decision. Embrace Connectomix TMS.

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Want to know more about Connectomix TMS therapy? Send us your details and we'll call you back.

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